...stimulus943.011696GO:0060068vagina development53.247818GO:0031558induction of apoptosis in response to chemical stimulus53.217217GO:0045931positive...0061039ovum-producing ovary development722.941252GO:0060393regulation of pathway-restricted SMAD protein phosphorylation222.829547GO:0060402calcium ion...perception of light stimulus2022.84478GO:0008624induction of apoptosis by extracellular signals1192.779105GO:0060850regulation of transcription...of protein dephosphorylation132.156973GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation182.161926GO:0032096negative regulation...

...of the EK cells are cleared by apoptosis and also autophagy (Vaahtokari et al., 1996...Wnt/Bmp inhibitor Ectodin/Sostdc1/Wise, no apoptosis was detected, but instead ectopic Wnt reporter...as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as...and P.T. Sharpe. 1998. The Shh signalling pathway in tooth development: Defects in Gli2 and...

...genes are involved in transcriptional regulation, transport, apoptosis, cell cycle regulation, and ubiquitin conjugation (Fig...with autophagy are not linked with this pathway but simply connected with one or more...

...binding blocks intrinsic and extrinsic cell death pathways. Proc. Natl. Acad. Sci. USA. 102:1466â...integration of energy metabolism and control of apoptosis. Curr. Med. Chem. 10:1535–1551...

...SARM1, not MyD88, mediates TLR7/TLR9-induced apoptosis in neurons. J. Immunol. 195:4913â€...activation of an injury-induced axon death pathway. Science. 337:481–484. doi:10...

...and morphology and renders cells susceptible for apoptosis, illustrating the critical role of mitochondrial lipid...can be synthesized using different cellular metabolic pathways (Birner et al., 2001; Fig. 2 A...negative genetic interactions with the cardiolipin synthesis pathway (Hoppins et al., 2011), reminiscent of components...synthesized within mitochondria along two Psd1-dependent pathways (Fig. 5 E): first, Ups2–Mdm35â...

...anti-cancer effect (i.e., promotion of apoptosis, inhibition of proliferation) the drug is predicted to have. The penalty term quantifies the pro-cancer effect the drug is predicted to have (i.e., promotion of proliferation, inhibition of apoptosis). Analyze with GOPredictExample inputSubmit your own data...and literature data (submitted)LinksAnduril bioinformatics frameworkMoksiskaan pathway integration tool for Anduril Developed in Systems...

...Drug-Path: a database for drug-induced pathways. Database (Oxford). 2015 Jun 30;2015:bav061...C. MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6...discovery of single gene, multiple genes, and pathways by enrichment analysis of their microRNA regulators...

...mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells: Leukemia & Lymphoma: Vol...CrossRef citations Altmetric be0ef6915d1b2200a248b7195d01ef22 Original Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cellsJun Ji Department of...a monocyclic monoterpene, in human leukemia cells. Apoptosis was evaluated by Hoechst staining and by...

...is mediated by the endoplasmic reticulum stress pathway: Leukemia & Lymphoma: Vol 48, No 5 Access provided by Kokuritsu Idengaku-Ken Log in  |  Register Cart Search in: This Journal Anywhere Journal Leukemia & Lymphoma Volume 48, 2007 - Issue 5Submit an article Back to journal 101 Views 10 CrossRef citations Altmetric be0ef6915d1b2200a248b7195d01ef22 Original Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells...

...cells to DNR, and led to cellular apoptosis through activation of the caspase-3 pathway. It is concluded that using BrTet in...

...A.. (2001) . Modulator of heme biosynthesis induces apoptosis in leukemia cells. J. Clin. Laser Surgery...and end products of the chlorophyll biosynthetic pathway. In Heme, Chlorophyll, and Bilins: Methods and...

...also investigated the neuroprotection of RSV associated with the AMPK and SIRT1 signaling pathways and cellular energy status in recurrent stroke models.Materials and methodsEthics statement and...staining on the alternating cryosections (20 μm). The morphological differences between necrosis and apoptosis regions were observed, the necrosis ischemia core was removed and the apoptosis penumbra region was kept. SIRT1 activity was measured using a deacetylase fluorometric assay...

...2008. Lysosomes in iron metabolism, ageing and apoptosis. Histochem. Cell Biol. 129:389–406...1986. Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 55:663–700...

...a pathophysiological study on pulmonary microvascular permeability, apoptosis, inflammation and coagulation.- TRIAL IDNTR745- ACRONYMINFALIReduction of...levonorgestrel containing oral contraceptive on the anticoagulations pathways.- TRIAL IDNTR408- ACRONYMMEN-Study (Microgynon 30-EVRA...

...members of the inflammasome include the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD, also known...Muckle-Wells syndromes.This family also includes NLR family, apoptosis inhibitory protein (NAIP, Q13075) which can be found in the 'Inhibitors of apoptosis (IAP) protein family' in the Other protein targets section...

...for maxi Cl- channels as a conductive pathway in the swelling-induced release of ATP...protein phosphatase PP2A occurs in the activation pathway [20]. In contrast, 17β-estradiol and tamoxifen...transcellular Cl- transport, angiogenesis, cell proliferation, necrosis, apoptosis, glutamate release from astrocytes, insulin(INS, P01308...PIK3-NOX-H2O2 and Src-PLC-Ca2+ pathways; regulation by PKC required for optimal activity...

...to form the mature protein. Members of the mammalian inhibitors of apoptosis proteins (IAP) are able to bind the procaspases, thereby preventing maturation...inhibited by dopamine and other catecholamines in a physiological negative feedback pathway [102].––Further ReadingAmireault P et al. (2013) Life without peripheral serotonin...itself be decarboxylated to form agmatine, although the prominence of this pathway in human tissues is uncertain. L-Arginine may be used as a precursor for guanidoacetic acid formation in the creatine synthesis pathway under the influence of arginine:glycine amidinotransferase with L-ornithine as...

...Hanahan, Cell, 2011, 144, 646-674]. Processes such as DNA damage, mitotic stress, genomic instability, apoptosis, senescence, growth signalling, angiogenesis, inflammation and infection play major roles in cancer biology. Actually, resisting...database (celldeathproteomics.uio.no) as a start point of this division, collecting proteomics data of apoptosis, autophagic cell death, excitotoxicity, necroptosis, paraptosis, pyropotosis, mitotic catastrophe, and Wallerian degeneration.The second division...

...lack of any changes in the KC apoptosis between WT and Cbx4KO mice (Fig. S3...KCs predominantly via the Polycomb-mediated inhibitory pathway.Cbx4 is a direct p63 target mediating...by modulating the activity of the Wnt pathway. J. Cell Biol. 207:549–567...in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss...

...modification•abolished RNA modification•increased frequency of apoptosis•normal apoptosis•abolished autophagy•delayed onset of autophagy•normal...decreased protein degradation via N-end rule pathway during vegetative growth•nucleus mislocalized towards cell...Copper fist DNA binding domain•Inhibitor of Apoptosis domain•Voltage gated chloride channel•POLO box...Rad4 beta-hairpin domain 3•RAM signalling pathway protein•C-terminal, D2-small domain, of...

...zebrafish cardiomyocyte proliferation (126). All of these pathways/regulators have previously been shown to be...cardiomyocyte proliferation. They identified several Jak1/Stat3 pathway members by screening translating RNAs in zebrafish...DNA synthesis in cardiomyocytes without activation of apoptosis. Circ Res 96: 509–517, 2005...YJ. Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets. Pharmacol Ther 135: 337â...

...to induce Wallerian degeneration. These results indicate the pathophysiological significance of the EGFR–ZNRF1 pathway induced by oxidative stress in the regulation of neuronal apoptosis and Wallerian degeneration. A deeper understanding of the regulatory mechanism for ZNRF1 catalytic activity via...et al., 2012). We previously reported that the ZNRF1–AKT–GSK3B–CRMP2 pathway promotes axonal degeneration. The E3 ubiquitin ligase zinc and ring finger 1 (ZNRF1) is constitutively...

...tumorigenesis (Fig. 10 C). Cell proliferation or apoptosis of the bulk tumor population were not...effects on bulk tumor cell proliferation or apoptosis (Fig. 10 J). Of note, the SFE...of any effect on cell proliferation and apoptosis, assessed by Ki-67 and activated caspase...obtained by IHC). A minimal effect on apoptosis, but not on proliferation, was observed at...

...of studies, the molecular features and signal pathways modulating apoptosis have been resolved in great details. Autophagy constitutes a stress adaptation that avoids cell death while induces an alternative pathway to cellular demise that is called autophagic...

...model of cell fate decisions between survival, apoptosis and non-apoptotic cell death (such as...proteins involved in Fanconi anemia DNA repair pathway as it is defined in Atlas of...

...component disassembly involved in execution phase of apoptosis| cellular respiration| electron transport chain| execution phase of apoptosis| mitochondrial ATP synthesis coupled electron transport| mitochondrial...development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway...

...cell survival and downregulation of apoptosis-related pathways [19,20]. Furthermore, hypoxic preconditioning also induces the expression of pro-survival markers [21], chemoattractants [22] and growth factors involved in cell proliferation, anti-oxidation, anti-apoptosis and angiogenesis [23] in MSCs. Hypoxic preconditioning...of antioxidant defense, cell survival and anti-apoptosis [39,40]. To determine the mitochondrial functions...

...of primordial germ cells and germ cell apoptosis at 13.5 dpc) did not prevail beyond F2.In another example, nuclear small RNA/chromatin pathway can maintain transgene repression for many generations...

...set network enrichment form Fatigo Examplesmotor vs apoptosis Define your comparison Id list vs Id...deleterious mutations, locate them over the signalling pathways in the selected tissue (with the appropriate...

...protein synthesis, cell proliferation, cell differentiation and apoptosis. In the last years, different mathematical models...simple description of a number of signalling pathway characteristics, such as the phosphorylation of signalling...

...Ishizu et al., 2014). Thus, the actual pathways of platelet biogenesis are not clear, and...living mice. Ultimately, we identified an alternative pathway entailing MK rupture–enhanced platelet release...J) Time-lapse images of FasL-induced apoptosis (5 µg/mouse, i.v.). Note that...MK rupture) and FasL-treated mice (for apoptosis). Bars: (red) 20 µm; (blue) 5 µm...

...INHIBITOR 3TIMP-2TIMP-3TIMP1TIMP2TIMP3TIMP4TINAGL1TIOTIP30TIP60TISTISSUE FACTOR PATHWAY INHIBITOR 2TISSUE FACTOR PATHWAY INHIBITOR-2TISSUE INHIBITOR OF METALLOPROTEINASE 3TISSUE INHIBITOR OF METALLOPROTEINASE-3TISSUE-TYPE PLASMINOGEN ACTIVATORTITF1TJP2TK1TKDTKOTKTL1TKTL2TLCTLE1TLL1TLRTLR-2TLR-4TLR-7TLR-9TLR1TLR13TLR2TLR3TLR4TLR5TLR6TLR7TLR8TLR9TLSTLX1TLX3TM1TM3TM6SF1TMATMETMEFF2TMEM106ATMEM127TMEM131TMEM151ATMEM173TMEM184ATMEM204TMEM25TMEM30BTMEM37TMEM7TMEM88TMK-1TMLTMMTMPRSS2TMPRSS3TMSTMS-1TMS1TMSB10TN-CTNDMTNFTNF ALPHATNF-ALPHATNF-BETATNF-RELATED APOPTOSIS-INDUCING LIGANDTNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR...

...hallmark of metastatic dissemination is resistance to apoptosis (Hanahan and Weinberg, 2000). Previously, a kinome-wide loss-of-function screen identified SIK1 as a regulator of p53-dependent anoikis, a specific type of apoptosis caused by loss of integrin-mediated adhesion...the Hippo–Yes-associated protein (YAP) pathway in human cells identified LKB1 and MARK...

...top, enter a term like *p53* or *apoptosis*. Press return. 1. Double-click on a pathway listed below to open the pathway. ### Importing...

...by inhibiting RIPK1 kinase activity-mediated hepatocyte apoptosis. Cancer Cell 28:582-98, 2015LinkFinkin S...A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization. Oncogene...M. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 513:90-4, 2014...

...A,'Anticonvulsants') 7,1 SEP(A) :- drug_has_target(A,B,inhibitor), GO_term(B,'apoptosis'), drug_has_target(A,C,inhibitor), GO_term(C,'protein modification process') 11,0 SEP...acid',HPCCchem) 5,1 SEP(A) :- drug_has_target(A,B,inhibitor), interact(B,C), pathway(C,'Role of Calcineurin-dependent NFAT signaling in lymphocytes',PID), drug_cluster(A,'18_nalidixic acid',HPCCchem) 5,0 SEP(A) :- drug_has_target(A,B,activator), interact(B,C), GO_term(C,'regulation of apoptosis') 7,1 SEP(A) :- drug_has_target(A,B,inhibitor), interact(B,C), pathway(C...

...Current theories concerning disease pathogenesis include an imbalance between protease and anti-protease activity, induced apoptosis of alveolar cells through deregulation of pathways involved in oxidative stress, chronic inflammation, and aberrant tissue remodeling that lead to the destruction...Lm), a morphological measurement of alveolar destruction [12]. In order to gain insights into biological pathways associated with increasing emphysema severity within a patient and explore computational strategies for identifying COPD...

...53385110ANK1286B3KX393386111GRK62870G protein coupled receptor kinase 63387111MKNK22872B3KS073388110GPS12873G protein pathway suppressor 13389111GPS22874Q132273390110GPT2875Glutamate pyruvate transaminase3391111GPX12876Glutathione peroxidase 13392110ANK2287Ankyrin 23393110GPX72882Glutathione...35206110C1RL51279Complement C1r like proteinase5207111CDK165127PCTAIRE protein kinase 15208111GOLM151280B3KNK95209111SCAND151282P570865210111BFAR51283Bifunctional apoptosis regulator5211110TLR751284B2R9N95212111RASL1251285RAS like family 12 protein5213111CEND151286BM88 antigen5214110CDK175128A8K1U65215110GMIP51291GEM interacting protein5216111ECSIT51295Signaling intermediate in Toll pathway evolutionarily conserved5217110PLUNC51297Palate lung and nasal epithelium clone...proteins C and D5302110TRIAP151499TP53 regulated inhibitor of apoptosis 15303110PDE6H5149Phosphodiesterase 6H cGMP specific cone gamma5304110C20orf4351507C20orf43 protein5305111CHMP551510SNF7...

...the wnt, Jak- Stat, MAPK, mTOR, VEGF, Apoptosis and Notch that are deregulated in breast cancer, using different online softwares and databases. Here we present oncomiRdbB, a comprehensive and integrated database of miRNAs, targets, their hubs and networks of various pathways which are involved in Breast cancer initiation...

...a great variety of other well conserved cellular processes, including cell proliferation [80, 81] and apoptosis [82]. The contribution of inflammation in general and NF-κB in particular to cancer initiation...by mutations of NF-κB genes and/or oncogenes that activate the NF-κB signaling pathway. On the other hand, a tumor can achieve elevated NF-κB activity through increased cytokine...

...annotated information of apoptotic genes such as pathway information, GO terms, relevant literature, and provides additional links to protein information, gene expression and interaction data. yApoptosis is a part of the broader yCellDeath project. More data and tools will be continuously added, and the apoptosis networks will be revised and updated on...

...GlycogenPhosphorylase_Activation notesBIOMD0000000101: Vilar2006_TGFbeta notesBIOMD0000000102: Legewie2006_apoptosis_WT notesBIOMD0000000103: Legewie2006_apoptosis_NC notesBIOMD0000000104: Klipp2002_MetabolicOptimization_linearPathway(n=2...Singh2006_TCA_mtu_model1 notesBIOMD0000000220: Albeck2008_extrinsic_apoptosis notesBIOMD0000000221: Singh2006_TCA_Ecoli_acetate notesBIOMD0000000222: Singh2006...notesBIOMD0000000242: Bai2003_G1phaseRegulation notesBIOMD0000000243: Neumann2010_CD95Stimulation_NFkB_Apoptosis notesBIOMD0000000244: Kotte2010_Ecoli_Metabolic_Adaption notesBIOMD0000000245: Lei2001...Topp2000_BetaCellMass_Diabetes notesBIOMD0000000342: Zi2011_TGF-beta_Pathway notesBIOMD0000000343: Brannmark2010_InsulinSignalling_Mifamodel notesBIOMD0000000344: Proctor2011_ProteinHomeostasis...

...tumorigenicity, dominant negative effects, capacity to induce apoptosis, cell-cycle arrest or checkpoints in human...identifier [Term] id: EDAM_data:2342 name: Pathway or network name subset: bioinformatics subset: data...

...that loss of Atg7 leads to widespread apoptosis in brains of 30-d-old mutant...the pancaspase inhibitor DIAP1 (Drosophila inhibitor of apoptosis protein 1) failed to rescue locomotion defects...specific steps of the autophagy/multivesicular body pathways. Biochim. Biophys. Acta. 1793:1901–1916...

...Hanahan, Cell, 2011, 144, 646-674]. Processes such as DNA damage, mitotic stress, genomic instability, apoptosis, senescence, growth signalling, angiogenesis, inflammation and infection play major roles in cancer biology. Actually, resisting...database (celldeathproteomics.uio.no) as a start point of this division, collecting proteomics data of apoptosis, autophagic cell death, excitotoxicity, necroptosis, paraptosis, pyropotosis, mitotic catastrophe, and Wallerian degeneration.The second division...

...that loss of Hk2 did not induce apoptosis. Scale bars = 1,000...results with a comparison of proliferation and apoptosis by Western blot analysis for specific markers...previously found that medulloblastomas demonstrate continuous baseline apoptosis demonstrable with cC3 staining[35]. Interestingly, both...activation of Shh and insulin/IGF/PI3K pathways. Importantly, we identified Myc–Max-mediated...

...cultured cells (Liu et al., 2010), in regulating apoptosis of germ cells in the embryo (Sato et al., 2007), and in the development of the adult brain (King et al., 2011). Two recent studies show that Tao is also involved in growth regulation of imaginal discs, in which Tao activates the Salvador–Warts–Hippo (SWH) pathway by phosphorylating Hippo kinase (Boggiano et al., 2011...

...they are involved, including growth and proliferation, apoptosis, and developmental timing (4).Piwi-interacting RNAs...GJ, Brennecke J (2007) The Piwi-piRNA pathway provides an adaptive defense in the transposon...

...database HomeResearchMembersCoursesGrants and AwardsJobs and OpeningsExtending signalling pathways with protein-interaction networks. Application to apoptosis.Extending signalling pathways with protein-interaction networks. Application to apoptosis. Joan Planas-Iglesias, Emre Guney, Javier Garcia...numerical results for the paper "Extending signalling pathways with protein-interaction networks. Application to apoptosis.". In this work, we build four different...