...transporters Acute myeloid leukemia Acylglycerol degradation Adenine ribonucleotide biosynthesis, IMP => ADP,ATP Adherens junction Adipocytokine signaling pathway Adrenergic signaling in cardiomyocytes African trypanosomiasis Alanine, aspartate and glutamate metabolism Alcoholism Aldosterone-regulated sodium reabsorption Allograft rejection alpha-Linolenic acid metabolism Alzheimer's disease Aminoacyl-tRNA biosynthesis Aminoacyl-tRNA biosynthesis, eukaryotes Amino sugar and nucleotide sugar metabolism Amoebiasis Amphetamine addiction AMPK signaling pathway Amyotrophic lateral sclerosis (ALS) Antigen processing and presentation Apoptosis Arachidonic acid metabolism Arginine and proline...

...Factors / Gene Regulatory NetworksDetailsProteome - . Protein-Protein Interactions. Metabolic Pathways. Signaling PathwaysDetailsTRRD - Transcription Regulatory Regions Database. Signaling Pathways. Transcription Factors / Gene Regulatory NetworksDetailsFreeABCdb - Archaea and Bacteria ABC Systems database. Protein Sequence FocusedDetailsFreeBioCarta - BioCarta Pathway Diagrams. Pathway DiagramsDetailsFreeCOMPEL - Database on Composite Regulatory Elements. Transcription Factors / Gene Regulatory NetworksDetailsDRC - Database of Ribosomal Crosslinks . Protein-Protein InteractionsDetailsFreeFIMM - Functional Molecular Immunology. Protein-Protein InteractionsDetailsGeneNet - Genetic Networks. Metabolic Pathways. Signaling Pathways. Genetic Interaction NetworksDetailsFreeGOLD.db - Genomics of Lipid-associated Disorders. Metabolic Pathways. Signaling PathwaysDetailsFreeHet-PDB_Navi...

...DNA metabolic process| mitochondrial DNA replication| mitochondrial genome maintenance| mitochondrion organization| negative regulation of apoptotic signaling pathway| negative regulation of cell proliferation| negative regulation of intrinsic apoptotic signaling pathway| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator| negative regulation of signal transduction by p53 class mediator| oxidoreduction coenzyme...

...CORrelation NETworksDetailsFreeCORUM - Comprehensive resource of mammalian protein complexesDetailsFreePSI-MICOXPRESdb - Coexpressed Gene DatabaseDetailsFreeCPDB - ConsensusPathDBDetailsPSI-MICSP - Cytokine Signaling Pathway DatabaseDetailsCTDB - Calmodulin Target DatabaseDetailsFreeCutDB - CutDB: Proteolytic Event DatabaseDetailsFreeCyclonet - CyclonetDetailsFreeDAnCER - Disease Annotated Chromatin Epigenetics ResourceDetailsFreeDAPID - Domain...Pathway ToolsDetailsFreeBioPAXSignaling Gateway - UCSD-Nature Signaling Gateway Molecule PagesDetailsFreeBioPAXSBMLSignaLink 2 - SignaLink 2: a multi-layered signaling pathway resourceDetailsPSI-MIBioPAXSBMLSnap - a Single Nucleotide Polymorphism Annotation PlatformDetailsFreeSNAPPI-DB - Structures, iNterfaces and Alignments for Protein...

...CORrelation NETworksDetailsFreeCORUM - Comprehensive resource of mammalian protein complexesDetailsFreePSI-MICOXPRESdb - Coexpressed Gene DatabaseDetailsFreeCPDB - ConsensusPathDBDetailsPSI-MICSP - Cytokine Signaling Pathway DatabaseDetailsCTDB - Calmodulin Target DatabaseDetailsFreeCutDB - CutDB: Proteolytic Event DatabaseDetailsFreeCyclonet - CyclonetDetailsFreeDAnCER - Disease Annotated Chromatin Epigenetics ResourceDetailsFreeDAPID - Domain...Pathway ToolsDetailsFreeBioPAXSignaling Gateway - UCSD-Nature Signaling Gateway Molecule PagesDetailsFreeBioPAXSBMLSignaLink 2 - SignaLink 2: a multi-layered signaling pathway resourceDetailsPSI-MIBioPAXSBMLSnap - a Single Nucleotide Polymorphism Annotation PlatformDetailsFreeSNAPPI-DB - Structures, iNterfaces and Alignments for Protein...

...as GSK3-β, p38, or PI3K, which modulate NF-κB transcriptional activity or affect upstream signaling pathways. Other classes of molecules that act as nodes of crosstalk are reactive oxygen species and...phosphorylations and other post-translational modifications which are important for activation and crosstalk with other signaling pathways [11]. Binding of NF-κB dimers to IκB molecules does not only prevent binding to...

...on the Insulin/Insulin-like Growth Factor Signalling Pathway in Drosophila melanogaster and Caenorhabtitis elegans and...for analysisThe Insulin/Insulin-like Growth Factor Signaling Pathway in Caenorhabtitis elegans. The Insulin/Insulin-like Growth Factor Signaling Pathway in Drosophila melanogaster. The Insulin/Insulin-like Growth Factor Signaling Pathway in Mus musculus. How to cite NetEffectsUsing Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing...

...011569765 100523 NRF-1 10 Source10 22 0.028757727 0.015443208 0.012683541 1052784 ATM Signaling Pathway 5 Source5 23 -0.015123263 -0.003610635 0.012731354 148316 Polysaccharide Catabolism: BP 18 Source18 24 -0.015123263...Neuroprotection Through NF-kB 5 Source5 31 0.022080099 0.009795561 0.016803424 1052782 AKT Signaling Pathway 5 Source5 32 0.023272627 0.009217272 0.016942591 1053014 Ras-Independent Pathway In NK...

...therapies specifically designed to blunt multiple, alternative signaling pathways. Abstract: Successful use of anti-cancer designer drugs is likely to depend on simultaneous combinations of these drugs to minimize the development of resistant cancer cells. Considering the knowledge base of cancer signaling pathways, mechanisms of designer drug resistance should be...

...       GO:0030521:androgen receptor signaling pathway                                         GO:0030518:steroid hormone receptor signaling pathway          ...

...A Tool for the Detection of Linear Signaling Pathways in Protein Interaction NetworksYou will need to activate JavaScript for the email links to work properly. FASPAD: A Tool for the Detection of Linear Signaling Pathways in Protein Interaction Networks IntroductionFrom this page you can download a tool to detect signaling pathway candidates in protein interaction networks as described...

...1 SEP(A) :- drug_has_target(A,B,inhibitor), interact(B,C), pathway(C,'RAC1 signaling pathway',PID) 13,1 SEP(A) :- drug_cluster(A,'7_marinol',HPCCcombo) 8,1 SEP(A...A) :- drug_has_target(A,B,activator), GO_term(B,'G-protein coupled receptor protein signaling pathway'), pathway(B,'Neuroactive ligand-receptor interaction',KEGG), drug_cluster(A,'19_halothane',HPCCchem) 5,0...

...nucleotide receptor activity ; GO:0045028 InterPro:IPR000018 P2Y purinoceptor 4 > GO:G-protein coupled receptor signaling pathway ; GO:0007186 InterPro:IPR000018 P2Y purinoceptor 4 > GO:transepithelial chloride transport ; GO:0030321 InterPro:IPR000018...melatonin receptor activity ; GO:0008502 InterPro:IPR000025 Melatonin receptor family > GO:G-protein coupled receptor signaling pathway ; GO:0007186 InterPro:IPR000025 Melatonin receptor family > GO:integral component of membrane ; GO:0016021 InterPro...

...scientific literature supporting crosstalk between pairs of signaling pathways.Take a tourAdherens junctionAdipocytokine signaling pathwayApoptosisErbB signaling...pathwayWnt signaling pathwaySearchExamples:   Wnt signaling pathway  Notch signaling pathway and TGF-beta signaling pathwayHow can I...path-based approach for detecting crosstalk between signaling pathways.Crosstalk graphs generated using XTalk shared on...

...proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.Description: Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.SpeciesList: scientific name: Drosophila...proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster. Proteomics, 15(4):725...proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.Subscribe to receive all...

...the apoptosis, inflammation, necrosis, and immune cell signaling pathways. Critical caspase activating complexes in the apoptosis and inflammation signaling pathways are assembled via the DD superfamily. These...events, such as apoptosis, inflammation, immune cell signaling pathway. Accumulating information on the PPIs in many cellular signaling pathways provides crucial insights into understanding the molecular...

...receptor pathwayDNA synthesis pathwayEGF pathwayEndothelin pathwayEndothelin-1 signalling pathway Estrogen pathwayFatty acid synthesis pathwayFibrin formation pathwayGlucocorticoid pathwayGlucocorticoid synthesis pathwayGlucose transport pathwayGlycogen synthesisGlycolysis pathwayGnRH pathwayHexose monophosphate pathwayHistamine pathwayHypersensitive pathwayIFN pathwayIGF pathwayInsulin pathway Integrin-dependent intracellular signalling pathway Interleukin-1 pathwayInterleukin-18 pathwayInterleukin-6 pathwayIP3...independent pathwayNF-kB activation pathwayNF-kB pathwayNociceptor signaling pathway Noradrenaline PathwayNoradrenaline synthesis pathwayNOS pathway NPY pathwayp53...

...Apoptosis database HomeResearchMembersCoursesGrants and AwardsJobs and OpeningsExtending signalling pathways with protein-interaction networks. Application to apoptosis.Extending signalling pathways with protein-interaction networks. Application to apoptosis...complete numerical results for the paper "Extending signalling pathways with protein-interaction networks. Application to apoptosis...or not.References1A logic-based diagram of signalling pathways central to macrophage activation2STRING: known and predicted...

...charset=us-ascii PathwayLinker: Linking proteins to signaling pathways for the design and evaluation of experimentshttp://PathwayLinker.org/2/00_test.cgi text/html; charset=us-ascii PathwayLinker: Linking proteins to signaling pathways for the design and evaluation of experimentsHelp · Search · Download · API   « Contact us  PathwayLinkerLink proteins to signaling pathways · Design & evaluate experimentsWelcome!Your browser...

...lab for analyzing microarrays, cis-regulation, and signaling pathways .  TAU Bioinformatics Unit. Some of our...lab for analyzing microarrays, cis-regulation, and signaling pathways .  TAU Bioinformatics Unit. December 2011: Expander...lab for analyzing microarrays, cis-regulation, and signaling pathways .  Bar-Ilan Bioinformatics Unit. April 12 2011: Expander hands on workshop Advanced tools from the Shamir lab for analyzing microarrays, cis-regulation, and signaling pathways .  TAU Bioinformatics Unit. March 31st 2011...

...is a database of highly curated human signaling pathways with an associated interactive software tool. Users...database, visualization and analysis tool of cellular signaling pathways". BMC Bioinformatics 9:110 (2008) [2] Arnon Paz, Zippora Brownstein, Yaara Ber, Shani Bialik, Eyal David, Dorit Sagir, Igor Ulitsky, Ran Elkon, Adi Kimchi, Karen B. Avraham, Yosef Shiloh and Ron Shamir "SPIKE: a database of highly curated human signaling pathways". Nucleic Acids Research, 2011, Vol. 39, Database...

...in GPCR Signaling and Msp/Ron Receptor Signaling Pathway                                    ¡¡¡¡2. Trka Receptor Signaling Pathway and D4-GDI Signaling Pathway¡¡      ...

...0009653: morphogenesis *[BP] GO:0016055: Wnt receptor signaling pathway[BP] GO:0030178: negative regulation of Wnt...matrix adhesion *[BP] GO:0007229: integrin-mediated signaling pathway[CC] GO:0008305: integrin complex[CC] GO...matrix adhesion *[BP] GO:0007229: integrin-mediated signaling pathway[CC] GO:0008305: integrin complex[CC] GO...0007154: cell communication *[BP] GO:0007219: Notch signaling pathway[BP] GO:0007275: development *[BP] GO:0007399...

...and self-renewal. More than a dozen signaling pathways are implicated in self-renewal, suggesting regulation...with mESC self-renewal or annotated to signaling pathways involved in early embryonic development, based on...data from network graph files for Developmental Signaling Pathway AnalysesDiscover novel genes predicted to be strongly...

...TimePath: Reconstructing temporal signaling pathwaysTimePath: Reconstructing temporal signaling pathways Download TimePathGithub repositoryManualData sourcesGO categoriesTemporal signaling pathway Most methods for reconstructing signaling and regulatory...

...pathways. ... CDA is a system for multi-signaling pathway targeting combinatorial drug discovery using gene expression profile. General expression pattern matching methods can be used to quantify the degree of functional similarity among genetic perturbation, disease, and drugs. CDA performs expression pattern matching within signaling pathway to measure functional similarity between input gene...

...here A rule-based model of insulin signalling pathway The insulin signalling pathway (ISP) is an important biochemical pathway, which...a simple description of a number of signalling pathway characteristics, such as the phosphorylation of signalling proteins at multiple sites with different effects, the simultaneous interaction of many molecules of the signalling pathways with several binding partners, and the information...

...cDSD, and augments it with high-confidence signaling pathway datacapDSD extends caDSD by making use of the topological properties of these signaling pathways If you use capDSD, please cite: M....

...Accurate models of the cross talk between signaling pathways and transcriptional regulatory networks within cells are...2, 2013. Identifying proteins controlling key disease signaling pathways. Anthony Gitter, Ziv Bar-Joseph. Bioinformatics. 29...

...number of components of the three main signaling pathways known to be initiated in response to...comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics. Proteomics, 15(2...

...path-based algorithm to reconstruct interactions in signaling pathways. halp, a library of algorithms for directed and undirected hypergraphs. XTalk, a path-based approach for detecting crosstalk between signaling pathways.Data-Driven Systems Biology Concise, Functional Enrichment...

...and thrombocytes, are formed through complex genetic signaling pathways that are highly conserved throughout phylogeny. Large-scale forward genetic screens have identified numerous blood mutants in zebrafish, helping to elucidate specific signaling pathways important for hematopoietic stem cells (HSCs) and...

...revealed shared Gene Ontology (GO) terms and signaling pathways within the clusters of co-expressed proteins (see Tables 1-2). To view all identified proteins (listed in Supplementary Table 2) click on the Reference gel. Tables: Table 1. Enriched GO terms and their p-values for co-expressed proteins Table 2. Signalling pathways and identified proteins involved. Supplementary Table 1...

...neuroprotection of RSV associated with the AMPK and SIRT1 signaling pathways and cellular energy status in recurrent stroke models.Materials...then harvested and analysed.Analysis of SIRT1 and AMPK signaling pathway induced by RSVTo understand whether SIRT1 and AMPK act...with the Neuman–Keuls post-test).AMPK and SIRT1 signaling pathway induced by RSV in recurrent ischemic strokeResults show that...

...from the scientific literature. They represent causal signaling pathways across a wide range of biological processes...within defined biological boundaries for inclusion of signaling pathways within particular context (species, tissues, cell types...

...we studied the effect of the loss of Eda signaling pathway on the early signaling center G1 cell population. At...signaling center functions to regulate budding morphogenesis via several signaling pathways. First, deficiency in Eda signaling leads to a smaller...Mo, C.C. Hui, and P.T. Sharpe. 1998. The Shh signalling pathway in tooth development: Defects in Gli2 and Gli3 mutants...

...this service is as follows:   VEGF signaling pathway Hematopoietic cell lineage GnRH signaling pathway Type II diabetes mellitus   Created: 2007...

...GO:7169 transmembrane receptor protein tyrosine kinase signaling pathway 1/2 GO:8543 FGF receptor signaling pathway 1/2 GO:7243 protein kinase cascade 1/2 GO:9887 organogenesis 1/2 GO:7167 enzyme linked receptor protein signaling pathway 1/2 GO:1501 skeletal development 1...

...cellular changes associated with stress and injury signalling pathways will be measured from metabolite/RNA extracts...cellular changes associated with stress and injury signalling pathways will be measured from metabolite/RNA extracts...

...actin cortical patch assembly•rRNA modification•phosphorelay signal transduction system•MAPK cascade involved in osmosensory signaling pathway•tryptophan biosynthetic process•MAPK cascade•inactivation of MAPK activity involved in osmosensory signaling pathway•chromatin silencing at rDNA•nuclear-transcribed mRNA catabolic process, nonsense-mediated decay•inactivation of MAPK...to DNA damage stimulus•DNA damage induced protein phosphorylation•response to oxidative stress•ER-nucleus signaling pathway•response to unfolded protein•response to sterol depletion•cellular response to nitrogen starvation•organelle organization...

...utilization 1/15 GO:8286 insulin receptor signaling pathway 1/15 GO:7388 posterior compartment specification...GO:7169 transmembrane receptor protein tyrosine kinase signaling pathway 1/2 GO:8543 FGF receptor signaling pathway 1/2 GO:7243 protein kinase cascade 1/2 GO:9887 organogenesis 1/2 GO:7167 enzyme linked receptor protein signaling pathway 1/2 GO:1501 skeletal development 1...

...the deleterious mutations, locate them over the signalling pathways in the selected tissue (with the appropriate expression pattern) and provides a comprehensive, graphic and interactive view of the predicted signal transduction probabilities across the different signalling pathways. Note: PATHiVAR web application makes an intensive...

...Whilst vertebrate rhodopsin activates the cyclic GMP signalling pathway, invertebrate rhodopsin activates the inositol-1,4,5-triphosphate signalling pathway via a Gq-type G protein. It...

...inflammation, such as the B-cell receptor signaling pathway, while genes decreasing in expression were enriched...with functions in the B-cell receptor signaling pathway were over-represented among the up-regulated...of components of the B cell receptor signaling pathway is associated with a change in the...several components of the B-cell receptor signaling pathway have increased expression in regions of severe...

...GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway[MF] GO:0016740: transferase activitycd00064: Furin-like...BP] GO:0019221: cytokine and chemokine mediated signaling pathway[BP] GO:0030595: immune cell chemotaxis[BP...

...ABA signaling. Figure 2.  Blue light signaling pathways in guard cells. Figure 3.  ABA signaling pathways in guard cells.Figure 1 is linked to...seedling development, indicating that GPA1 negatively regulates this signaling pathway (Pandey et al., 2006). Thus G proteins affect...indicating a signaling convergence between ABA and ethylene signaling pathways. However, ethylene was also shown to counteract and...

...agents, other than having an impact on immune signalling pathways, although many cytokines have effects on other systems...inflammatory or haematopoietic signalling. Although not an exclusive signalling pathway, a common feature of the majority of cytokine...subfamilies on the basis of sequence comparison and signalling pathways activated, the TGFβ/activin/nodal subfamily and the...

...available pathway map that comprehensively catalogs all signaling pathways in the field of Alzheimer's disease (AD...

...software to annotate biological information pertaining to signaling pathways and, with minimal additional effort, to create...

...expression  In silico expression analysis cis-elements Signaling pathways Description Documentation Contact Disclaimer   For complete...