...by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia...CrossRef citations Altmetric be0ef6915d1b2200a248b7195d01ef22 Original Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia...a monocyclic monoterpene, in human leukemia cells. Apoptosis was evaluated by Hoechst staining and by...

...neurons overexpressing ZNRF1 C184A or ZNRF1 Y103F (Fig. 5). We used the expression of cleaved caspase 3 and annexin V labeling as markers for activation of the prototypical apoptosis pathway (Elmore, 2007). We found that the numbers of cleaved caspase 3–positive cells (Fig. 5, A and B), cells with nuclei exhibiting highly fluorescent...

...IL-1α (Fig. 6, E and F). Immunofluorescence experiments also revealed the activation of caspase-3 and release of von Willebrand factor–positive granules, but TUNEL staining was negative, which makes this process different from typical FasL-induced apoptosis (Fig. 6, G–J). Caspase inhibition using Z-VAD (OMe)-FMK suppressed the effect of IL-1α on platelet...

...specificity phosphatase 5 CASP1 834 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) JUND 3727 Jun D proto-oncogene CASP10 843 Caspase 10, apoptosis-related cysteine peptidase IL1R2 7850 Interleukin 1...Transforming growth factor, beta 2 CASP4 837 Caspase 4, apoptosis-related cysteine peptidase MAP3K2 10746 Mitogen-activated...

...necrosis, and immune cell signaling pathways. Critical caspase activating complexes in the apoptosis and inflammation signaling pathways are assembled via...4) Death effector domain (DED) subfamily (5) Caspase recruitment domain (CARD) subfamily (6) Pyrin domain...1-3). Due to the fact that apoptosis, inflammation and immune receptor signaling events are...

...proteins which have 'apoptosis' as GO term.Caspase-3, -6 or -7, present in database as identified protein.Caspase-8, present in database as identified protein.List proteins which were identified in studies using CD95 as apoptosis inducer.cIAPs, partly present in database as...List proteins which have been identified as caspase substrates.List proteins which were identified in studies of the extrinsic apoptosis pathway.Death receptors, present in database as...

...proteins which have 'apoptosis' as GO term.Caspase-3, -6 or -7, present in database as identified protein.Caspase-8, present in database as identified protein.List proteins which were identified in studies using CD95 as apoptosis inducer.cIAPs, partly present in database as...List proteins which have been identified as caspase substrates.List proteins which were identified in studies of the extrinsic apoptosis pathway.Death receptors, present in database as...

...proteins which have 'apoptosis' as GO term.Caspase-3, -6 or -7, present in database as identified protein.Caspase-8, present in database as identified protein.List proteins which were identified in studies using CD95 as apoptosis inducer.cIAPs, partly present in database as...List proteins which have been identified as caspase substrates.List proteins which were identified in studies of the extrinsic apoptosis pathway.Death receptors, present in database as...

...activity 3 54585 protein_transport 3 54585 caspase_activation 3 54585 unfolded_protein_response 3 54585 magnesium_ion_binding 3 54585 protein_ubiquitination 3 54585 lipid_binding 3 54585 ER-associated_protein_catabolic_process 3 54585 double-strand_break_repair 3 54585 enzyme_binding 3 54585 regulation_of_apoptosis 3 55770 apoptosis 3 55770 anti-apoptosis...

...and XBP1 genes followed by cleavage of caspase-3 but not caspase-4 protein were also observed.RetractionKeywords: Homoharringtonine, apoptosis, ER stress, mitochondrial membrane potential...

...that loss of Atg7 leads to widespread apoptosis in brains of 30-d-old mutant adults (Juhász et al., 2007). On average, 25% of neurons were positive for active caspase 3 in the absence of Syx17 in...and I). Transgenic expression of the effector caspase inhibitor p35 in mutant neurons suppressed TUNEL...

...transcript CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) CASP1 caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) CASP10 caspase 10, apoptosis-related cysteine protease CASP3 caspase 3, apoptosis-related cysteine protease CASP5 caspase 5, apoptosis-related cysteine protease CASP6 caspase 6, apoptosis-related cysteine protease CASP7 caspase 7, apoptosis-related cysteine protease CASP8 caspase 8, apoptosis-related cysteine protease CASP8AP2 CASP8 associated protein 2 CASP9 caspase 9...

...and Reagents Annexin V Assay Apoptosis Analysis Caspase Profiling ApoPrimer Set DNA Fragmentation Assay In Situ Apoptosis Detection PARP Antibody Bone Research Bone Specific...

...SP6, rabbit monoclonal; Thermo Fisher Scientific); activated caspase-3 (Asp175, rabbit polyclonal, Cell Signaling Technologies...and Ki-67, Numb, Slug, and activated caspase-3 (same as for IF or IHC...of any effect on cell proliferation and apoptosis, assessed by Ki-67 and activated caspase-3 levels, respectively (see Fig. 10 J for similar results obtained by IHC). A minimal effect on apoptosis, but not on proliferation, was observed at...

...protein4642111MPP34356Membrane protein4643110MPZ4359Myelin protein zero4644110ASL435Argininosuccinate lyase4645110MRC14360Macrophage mannose receptor4646111MRE11A4361Q05D784647110ASNA1439ASNA14648110ACHE43Acetylcholinesterase4649110CARD17440068Inhibitory caspase recruitment domain protein4650110CCDC88C440193Coiled-coil domain containing 88C4651111EIF2AK4440275Similar...35206110C1RL51279Complement C1r like proteinase5207111CDK165127PCTAIRE protein kinase 15208111GOLM151280B3KNK95209111SCAND151282P570865210111BFAR51283Bifunctional apoptosis regulator5211110TLR751284B2R9N95212111RASL1251285RAS like family 12 protein5213111CEND151286BM88 antigen5214110CDK175128A8K1U65215110GMIP51291GEM interacting...proteins C and D5302110TRIAP151499TP53 regulated inhibitor of apoptosis 15303110PDE6H5149Phosphodiesterase 6H cGMP specific cone gamma5304110C20orf4351507C20orf43 protein5305111CHMP551510SNF7...carboxypeptidase-like protein 16205110CCAR155749Cell division cycle and apoptosis regulator 16206110AGK55750A4D1U56207110SEPT1155752Septin 116208111CDK5RAP255755Q96SN86209110INTS955756B7Z6M56210110UGGT255757Q05D906211111RCOR355758B3KYA26212110WDR1255759Q53T996213111PRKAR1B5575Protein kinase6214111TTC1755761Tetratricopeptide repeat protein 176215111EXOC155763Exocyst...

...cell CLL/lymphoma 7C ENSG00000106144 CASP2 835 Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]. ENSG00000111664 GNB3 2784 Guanine...2.7.1.37) (PSK-H1). ENSG00000171791 BCL2 596 Apoptosis regulator Bcl-2. ENSG00000187048 CYP4A11 1579 Cytochrome...

...protein. Members of the mammalian inhibitors of apoptosis proteins (IAP) are able to bind the procaspases, thereby preventing maturation to active proteinases.CommentsCARD16 (Caspase recruitment domain-containing protein 16, caspase-1 inhibitor COP, CARD only domain-containing protein 1, pseudo interleukin-1β converting enzyme, pseudo-ICE, ENSG00000204397) shares sequence similarity with some of the caspases.M1: Aminopeptidase NOverviewAminopeptidases catalyze the cleavage of...

...that loss of Hk2 did not induce apoptosis. Scale bars = 1,000...results with a comparison of proliferation and apoptosis by Western blot analysis for specific markers...previously found that medulloblastomas demonstrate continuous baseline apoptosis demonstrable with cC3 staining[35]. Interestingly, both...CarboxylaseAMPk: AMP-activated kinasecC3: Cleaved caspase-3CGN: Cerebellar granule neuronCGNP:...

...the inflammasome include the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD, also known as PYCARD, CARD5, TMS1, Q9ULZ3) and inflammatory caspases. The inflammasome activates the pro-inflammatory cytokines...syndromes.This family also includes NLR family, apoptosis inhibitory protein (NAIP, Q13075) which can be...

...SCOP: c.17.1.1 Inhibitor of apoptosis (IAP) repeat FROM: Human (Homo sapiens) SCOP...SCOP: b.47.1.2 37.37Details Caspase catalytic domain FROM: Human (Homo sapiens) SCOP: c.17.1.1 Baculovirus p35 protein FROM: AcMNPV (Autographa californica nuclear polyhedrosis virus) SCOP: b.28.1.1 Inhibitor of apoptosis (IAP) repeat FROM: Human (Homo sapiens) SCOP...

...H precursorapolipoprotein JApoptosis 1 inhibitor (Inhibitor of apoptosis 1) (dIAP1)apoptosis inhibitor; annihilatorApoptosis regulator Bcl-2Apoptotic chromatin...s1casein alpha-S2casein betaCASP8 and FADD-like apoptosis regulator; FLIPCaspase 1 isoform alpha precursorcaspase 10...cerevisiae)cytokeratin 8 (Homo sapiens)cytokine induced apoptosis inhibitor 1cytomegalovirus gBcytoplasmic activation/proliferation-associated protein...5Bevolutionarily related interleukin-1beta converting enzyme; Caspase-13Excinuclease ABC subunit Aexcitatory amino acid...

...InterPro:IPR003092 Two pore domain potassium channel, TASK family > GO:membrane ; GO:0016020 InterPro:IPR003093 Apoptosis regulator, Bcl-2 protein, BH4 > GO:regulation of apoptotic process ; GO:0042981 InterPro:IPR003094 Fructose...GO:0006547 InterPro:IPR003428 Mitochondrial glycoprotein > GO:mitochondrial matrix ; GO:0005759 InterPro:IPR003429 Baculovirus p35, apoptosis preventing protein > GO:cysteine-type endopeptidase inhibitor activity involved in apoptotic process ; GO:0043027 InterPro:IPR003429 Baculovirus p35, apoptosis preventing protein > GO:negative regulation of apoptotic process ; GO:0043066 InterPro:IPR003430 Methane/phenol/toluene...